No—
In the original work, Itachi gave Shisui's Mangekyo to Naruto; this was Itachi's contingency plan to correct Sasuke.
After Itachi's death, Sasuke might have been provoked by Obito to embark on a path of destroying Konoha.
At that time, Shisui's Mangekyo could forcibly brainwash Sasuke, making him protect Konoha.
The command Itachi set in Shisui's Mangekyo was—"When seeing Itachi's Mangekyo Sharingan, activate Kotoamatsukami and make the person who sees it protect Konoha."
As Itachi expected, after Sasuke killed him, he would awaken the Mangekyo, go blind, and then transplant Itachi's eyes to obtain the Eternal Mangekyo Sharingan.
When Naruto and Sasuke fought, Sasuke using Itachi's eyes to perform ocular jutsu on Naruto would trigger Shisui's Mangekyo inside Naruto's body.
At that point, Kotoamatsukami would brainwash Sasuke, making him protect Konoha.
Therefore, even the Eternal Mangekyo Sharingan cannot counter Kotoamatsukami.
It is estimated that only Six Paths level eyes, namely the Rinnegan or Tenseigan, can counter Kotoamatsukami.
Furthermore, the most formidable aspect of Kotoamatsukami is its 'first-sight kill' nature; no matter how powerful a Shinobi is, if they don't know about Shisui's Kotoamatsukami and aren't on guard immediately, it's easy to fail miserably.
Ryou already knew the intel on Shisui's Kotoamatsukami, so being prepared made it easier to counter the opponent.
First, don't let Shisui activate the Mangekyo Sharingan.
If the opponent activates the Mangekyo, immediately use clones to fight him while the main body hides underground.
In this way, Ryou would have no worries about the future.
Ryou then looked solemnly at Konan and Nagato: "No, you two must go back."
Konan and Nagato were somewhat puzzled; they had just agreed, so why was Ryou going back on his word now?
Konan asked: "Is there some hidden difficulty?"
Ryou had much to say and couldn't explain it clearly in a short time, so he reached out and signaled Konan to fist-bump, preparing for high-level communication in the form of chakra.
Konan didn't realize it for a moment.
Ryou reached out to hold her hand, transmitting the intel about Kotoamatsukami to Konan.
After Konan received Ryou's chakra, her expression became increasingly shocked—an illusion that could permanently change a person's will! No eye contact required; it could be launched silently just by seeing the target!
Wasn't this scheming enough?
The Uchiha, each one more scheming than the last.
"Konan, now you know why I want you to go back!"
Konan nodded, while Nagato stood by somewhat confused; what secrets were they whispering?
Konan was a bit worried: "The best way to break an illusion is a partner. If we leave and your will is modified, what then?"
Ryou comforted Konan: "Don't worry, I won't be controlled that easily."
"Konan, let's do a test. If after I return, you take out your underwear and I don't show a look of unbearable thirst..."
"Then it proves my will has been modified by Shisui!"
Konan angrily knocked Ryou on the head: "Why do I feel it might be better if he modified that evil brain of yours?"
"Alright, Konan, go back!"
"But..."
Ryou gradually lost his patience and held up a finger to threaten Konan: "Be good, go back for me!"
Konan's face flushed when she saw Ryou's finger, and she said somewhat angrily: "Fine, fine, Nagato and I will go back. I can't wait for an evil Uchiha like you to turn over a new leaf."
But at the critical moment, Konan softened, wrapped her arms around Ryou's neck, and kissed him: "You must be careful. Try to use clones to fight him."
"I know!"
Nagato watched from the side with a complex expression, becoming even more determined to create a world of illusions so he could have a Konan who liked him.
Konan released her hands from Ryou's neck and then, with Nagato, used Ryou's spore to activate the Mayfly Technique to disappear into the ground.
After Konan and Nagato left, Ryou only had Candy on his shoulder.
Ryou then used chakra to communicate with Candy, telling her the intel about Shisui's Kotoamatsukami.
The more Candy heard, the more shocked she became; even the lollipop in her hand didn't taste as good.
Candy responded to Ryou in horror via chakra: "This, this... no counter works? Isn't this way too scheming?"
Ryou said in Candy's mind: "Candy, listen to me. Kotoamatsukami is too unsolvable. Today, we not only need to take back the Seven-Tails, but we also have to destroy Shisui's Mangekyo."
Ryou then copied a portion of illusion energy formed from his own memories into Candy's body and set up a technique.
"Candy, I've sealed my illusion in your head. Later, if something is wrong with me, use the illusion in your mind on me."
Candy nodded.
The best way to break an illusion is to use a companion's power. If Ryou were controlled, Candy would make him relive his memories again.
In this way, if Ryou discovered anything wrong, he could modify his own cognition.
This was called 'Preserving the True Self'!
Ryou had prepared the necessary precautions; if he really was controlled by Shisui's Mangekyo, he would just have to accept it.
Through Shisui's Mangekyo, Ryou finally understood that although he was already powerful enough to approach the level of Madara and Hashirama, he couldn't afford to be reckless.
Even when facing someone weaker than himself, it was easy to fail.
Especially when facing people from the Uchiha; although Ryou was also an Uchiha, he had to admit that the Uchiha were each more scheming than the last.
No wonder Obito thought about wiping out the Uchiha Clan in the original work, because the power of the Uchiha was truly the root of trouble.
"Strange, why did Uchiha Ryou let all his subordinates retreat?"
Jiraiya, Shisui, Kakuzu, and the others were very confused to see Ryou letting his people retreat.
Nagato and Konan were not weak; if they stayed, they could solo Kakuzu.
The Kusagakure leader Shirakawa and Mui were also top-tier Jonin and skilled hands; why did Ryou let them retreat?
A Konoha Anbu guessed: "Maybe Uchiha Ryou saw Shisui use the Mangekyo to control the Seven-Tails and wants to back down."
No—
Jiraiya negated: "Ryou is even more powerful than you imagine. You must treat him as you would the First Hokage."
Jiraiya had seen Ryou's Wooden Golem, which was like a great Buddha.
A mountain-like Wooden Golem—one punch would turn the world upside down. The Seven-Tails was absolutely no match for such a Wooden Golem.
Susanoo took out the spiritual tool, the Gunbai, from its back, and Ryou shouted loudly at Jiraiya: "Jiraiya, hand over the Seven-Tails quickly, or I won't be polite to you."
Jiraiya roared back: "Ryou, you bastard, snatching Tsunade away to marry her was already being very impolite to me!"
Ryou pointed the Gunbai at Jiraiya: "I've already been very restrained. I didn't even snatch Kushina, your student's wife. Isn't that a favor to you?"